Objectives

The general objectives of this project are:

1. To determine the absolute and relative mortality from all causes and from cardiovascular disease in treated FH patients.
2. To analyse the relative risk of non-fatal cardiovascular events in this population.
3. To study the prognostic role of classic risk factors, dietary habits and genetic variability associated with favourable or unfavourable evolution in FH clinical expression.
4. To analyse the role of LDL-r mutation types in determining the risk of coronary disease.
5. To estimate the long-term quality of life of FH subjects and their families.