This is an open, multicenter, long-term prospective cohort study in a well-defined FH population, conducted in 30 outpatient lipid clinics in Spain.
SAFEHEART (The SpAnish Familial HypErcHolEsterolaemiA CohoRt STudy) was launched in 2004 thanks to the Spanish Familial Hypercholesterolemia Foundation, a Grant from the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Health through the Thematic Network of Cooperative Investigation in Genetic Hyperlipidemias G03/108 (2003-2006), and from a Grant 2008-08 (2009-11) of the Centro Nacional de Investigación Cardiovascular (CNIC).
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